Parrott, Neil : rechercher sur Z-Library

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1

A strategy for preclinical formulation development using GastroPlus™ as pharmacokinetic simulation tool and a statistical screening design applied to a dog study

Martin Kuentz, Sonja Nick, Neil Parrott, Dieter Röthlisberger

Journal:

European Journal of Pharmaceutical Sciences

Année:

2006

Langue:

english

Fichier:

PDF, 425 KB

english, 2006

2

In Vitro to in Vivo Extrapolation and Physiologically Based Modeling of Cytochrome P450 Mediated Metabolism in Beagle Dog Gut Wall and Liver

Heikkinen, Aki T., Fowler, Stephen, Gray, Lynn, Li, Jia, Peng, Ying, Yadava, Preeti, Railkar, Aruna, Parrott, Neil

Journal:

Molecular Pharmaceutics

Année:

2013

Langue:

english

Fichier:

PDF, 1.43 MB

english, 2013

3

Discovery of Balovaptan, a Vasopressin 1a Receptor Antagonist for the Treatment of Autism Spectrum Disorder

Schnider, Patrick, Bissantz, Caterina, Bruns, Andreas, Dolente, Cosimo, Goetschi, Erwin, Jakob-Roetne, Roland, Künnecke, Basil, Mueggler, Thomas, Muster, Wolfgang, Parrott, Neil, Pinard, Emmanuel, Rat

Journal:

Journal of Medicinal Chemistry

Année:

2020

Langue:

english

Fichier:

PDF, 3.39 MB

english, 2020

4

Best Practices in the Development and Validation of Physiologically Based Biopharmaceutics Modeling. A Workshop Summary Report.

Parrott, Neil, Suarez-Sharp, Sandra, Kesisoglou, Filippos, Pathak, Shriram M., Good, David, Wagner, Christian, Dallmann, AndrÃ©, Mullin, James, Patel, Nikunjkumar, Riedmaier, Arian Emami, Mitra, Amita

Journal:

Journal of Pharmaceutical Sciences

Année:

2020

Fichier:

PDF, 37 KB

2020

5

Applications of Physiologically Based Absorption Models in Drug Discovery and Development

Parrott, Neil, Lave, Thierry

Journal:

Molecular Pharmaceutics

Année:

2008

Langue:

english

Fichier:

PDF, 1.94 MB

english, 2008

6

Application of PBPK modeling to predict human intestinal metabolism of CYP3A substrates – An evaluation and case study using GastroPlus™

Aki T. Heikkinen, Guillaume Baneyx, Antonello Caruso, Neil Parrott

Journal:

European Journal of Pharmaceutical Sciences

Année:

2012

Langue:

english

Fichier:

PDF, 648 KB

english, 2012

7

A Novel Strategy for Physiologically Based Predictions of Human Pharmacokinetics

Dr Hannah M. Jones, Neil Parrott, Karin Jorga, Thierry Lavé

Journal:

Clinical Pharmacokinetics

Année:

2006

Langue:

english

Fichier:

PDF, 388 KB

english, 2006

8

Preclinical Reproductive and Developmental Toxicity Profile of a Glycine Transporter Type 1 (Glyt1) Inhibitor

Barrow, Paul, Parrott, Neil, Alberati, Daniela, Paehler, Axel, Koerner, Annette

Journal:

Birth Defects Research Part B: Developmental and Reproductive Toxicology

Année:

2016

Langue:

english

Fichier:

PDF, 341 KB

english, 2016

9

The Ontogeny of UDP-glucuronosyltransferase Enzymes, Recommendations for Future Profiling Studies and Application Through Physiologically Based Pharmacokinetic Modelling

Badée, Justine, Fowler, Stephen, de Wildt, Saskia N., Collier, Abby C., Schmidt, Stephan, Parrott, Neil

Journal:

Clinical Pharmacokinetics

Année:

2018

Langue:

english

Fichier:

PDF, 961 KB

english, 2018

10

Physiologically Based Pharmacokinetic Modelling for First-In-Human Predictions: An Updated Model Building Strategy Illustrated with Challenging Industry Case Studies

Miller, Neil A., Reddy, Micaela B., Heikkinen, Aki T., Lukacova, Viera, Parrott, Neil

Journal:

Clinical Pharmacokinetics

Année:

2019

Langue:

english

Fichier:

PDF, 3.04 MB

english, 2019

11

Simulating the Impact of Elevated Levels of Interleukin-6 on the Pharmacokinetics of Various CYP450 Substrates in Patients with Neuromyelitis Optica or Neuromyelitis Optica Spectrum Disorders in Different Ethnic Populations

Machavaram, Krishna K., Endo-Tsukude, Chihiro, Terao, Kimio, Gill, Katherine L., Hatley, Oliver J., Gardner, Iain, Parrott, Neil, Ducray, Patricia Sanwald

Journal:

The AAPS Journal

Année:

2019

Langue:

english

Fichier:

PDF, 2.40 MB

english, 2019

12

Impact of Intracellular Concentrations on Metabolic Drug-Drug Interaction Studies

Treyer, Andrea, Ullah, Mohammed, Parrott, Neil, Molitor, Birgit, Fowler, Stephen, Artursson, Per

Journal:

The AAPS Journal

Année:

2019

Langue:

english

Fichier:

PDF, 1.20 MB

english, 2019

13

Prediction of pH-Dependent Drug-Drug Interactions for Basic Drugs using Physiologically based Biopharmaceutics Modeling: Industry Case Studies

Mitra, Amitava, Parrott, Neil, Miller, Neil, Lloyd, Richard, Tistaert, Christophe, Heimbach, Tycho, Ji, Yan, Kesisoglou, Filippos

Journal:

Journal of Pharmaceutical Sciences

Année:

2019

Langue:

english

Fichier:

PDF, 5.61 MB

english, 2019

14

Physiologically Based Absorption Modelling to Explore the Impact of Food and Gastric pH Changes on the Pharmacokinetics of Entrectinib

Parrott, Neil, Stillhart, Cordula, Lindenberg, Marc, Wagner, Bjoern, Kowalski, Karey, Guerini, Elena, Djebli, Nassim, Meneses-Lorente, Georgina

Journal:

The AAPS Journal

Année:

2020

Fichier:

PDF, 1.69 MB

2020

15

In Vitro Biopredictive Methods: A Workshop Summary Report

Pepin, Xavier JH., Dressman, Jennifer, Parrott, Neil, Delvadia, Poonam, Mitra, Amitava, Zhang, Xinyuan, Babiskin, Andrew, Kolhatkar, Vidula, Seo, Paul, Taylor, Lynne S., SjÃ¶gren, Erik, Butler, James

Journal:

Journal of Pharmaceutical Sciences

Année:

2020

Fichier:

PDF, 1.70 MB

2020

16

Applications of Physiologically Based Biopharmaceutics Modeling (PBBM) to support Drug Product Quality: A Workshop Summary Report

Mitra, Amitava, Suarez-Sharp, Sandra, Pepin, Xavier JH., Flanagan, Talia, Zhao, Yang, Kotzagiorgis, Evangelos, Parrott, Neil, Sharan, Satish, Tistaert, Christophe, Heimbach, Tycho, Zolnik, Banu, SjÃ¶g

Journal:

Journal of Pharmaceutical Sciences

Année:

2020

Fichier:

PDF, 8.13 MB

2020

17

Correction to: In Vitro to In Vivo Extrapolation of Metabolic Clearance for UGT Substrates Using Short-Term Suspension and Long-Term Co-cultured Human Hepatocytes

Docci, Luca, Klammers, Florian, Ekiciler, Aynur, Molitor, Birgit, Umehara, Kenichi, Walter, Isabelle, KrÃ¤henbÃ¼hl, Stephan, Parrott, Neil, Fowler, Stephen

Journal:

The AAPS Journal

Année:

2020

Fichier:

PDF, 159 KB

2020

18

Two distinct phenotypes caused by two different missense mutations in the same codon of the VHL gene

Bradley, John F., Collins, Debra L., Schimke, R. Neil, Parrott, Heather N., Rothberg, Paul G.

Journal:

American Journal of Medical Genetics

Année:

1999

Langue:

english

Fichier:

PDF, 248 KB

english, 1999

19

A fast virtual screening filter for cytochrome P450 3A4 inhibition liability of compound libraries

Jochen Zuegge, Uli Fechner, Olivier Roche, Neil J. Parrott, Ola Engkvist, Gisbert Schneider

Journal:

Molecular Informatics

Année:

2002

Langue:

english

Fichier:

PDF, 139 KB

english, 2002

20

An evaluation of the utility of physiologically based models of pharmacokinetics in early drug discovery

Neil Parrott, Nicolas Paquereau, Philippe Coassolo, Thierry Lavé

Journal:

Journal of Pharmaceutical Sciences

Année:

2005

Langue:

english

Fichier:

PDF, 494 KB

english, 2005

21

Successful renal transplantation in children in the presence of thrombosis of the inferior vena cava

Mohan Shenoy, Ravi Pararajasingam, Neville B. Wright, Malcolm A. Lewis, Neil Parrott, Hany Riad, Nicholas J. A. Webb

Journal:

Pediatric Nephrology

Année:

2008

Langue:

english

Fichier:

PDF, 182 KB

english, 2008

22

Successful renal transplant during the first trimester of pregnancy

Louise C. Kenny, Philip N. Baker, Michael Venning, Neil Parrott

Journal:

Transplant International

Année:

2007

Langue:

english

Fichier:

PDF, 421 KB

english, 2007

23

Native nephrectomy for autosomal dominant polycystic kidney disease: before or after kidney transplantation?

Matthew A. Kirkman, David van Dellen, Sanjay Mehra, Babatunde A. Campbell, Afshin Tavakoli, Ravi Pararajasingam, Neil R. Parrott, Hany N. Riad, Lorna McWilliam, Titus Augustine

Journal:

BJU International

Année:

2011

Langue:

english

Fichier:

PDF, 250 KB

english, 2011

24

Application of Full Physiological Models for Pharmaceutical Drug Candidate Selection and Extrapolation of Pharmacokinetics to Man

Neil Parrott, Hannah Jones, Nicolas Paquereau, Thierry Lavé

Journal:

Basic & Clinical Pharmacology & Toxicology

Année:

2005

Langue:

english

Fichier:

PDF, 179 KB

english, 2005

25

Mass Spectrometry-Based Quantification of CYP Enzymes to EstablishIn Vitro/In VivoScaling Factors for Intestinal and Hepatic Metabolism in Beagle Dog

Aki T. Heikkinen, Arno Friedlein, Jens Lamerz, Peter Jakob, Paul Cutler, Stephen Fowler, Tara Williamson, Roberto Tolando, Thierry Lave, Neil Parrott

Journal:

Pharmaceutical Research

Année:

2012

Langue:

english

Fichier:

PDF, 321 KB

english, 2012

26

Prediction of intestinal absorption: comparative assessment of gastroplus™ and idea™

Neil Parrott, Thierry Lavé

Journal:

European Journal of Pharmaceutical Sciences

Année:

2002

Langue:

english

Fichier:

PDF, 637 KB

english, 2002

27

Islet cell transplantation: current status in the UK

Pratik Choudhary, Neil R Parrott, Linda Birtles, Martin K Rutter

Journal:

Practical Diabetes

Année:

2012

Langue:

english

Fichier:

PDF, 501 KB

english, 2012

28

Hypolipidaemic properties of a potent and bioavailable alkylsulphinyl-diphenylimidazole ACAT inhibitor (RP 73163) in animals fed diets low in cholesterol

David Riddell, Colin P. Bright, Brenda J. Burton, Raymond C. Bush, Neil V. Harris, David Hele, Una M. Moore, Kuni Naik, David P. Parrott, Christopher Smith, Robert J. Williams

Journal:

Biochemical Pharmacology

Année:

1996

Langue:

english

Fichier:

PDF, 1.23 MB

english, 1996

29

Acyl-CoA:Cholesterol O -Acyltransferase (ACAT) Inhibitors. 2. 2-(1,3-Dioxan-2-yl)-4,5-diphenyl-1 H -imidazoles as Potent Inhibitors of ACAT

Astles, Peter C., Ashton, Michael J., Bridge, Andrew W., Harris, Neil V., Hart, Terrance W., Parrott, David P., Porter, Barry, Riddell, David, Smith, Christopher, Williams, Robert J.

Journal:

Journal of Medicinal Chemistry

Année:

1996

Langue:

english

Fichier:

PDF, 568 KB

english, 1996

30

A Physiologically Based Pharmacokinetic Model of the Minipig: Data Compilation and Model Implementation

Claudia Suenderhauf, Neil Parrott

Journal:

Pharmaceutical Research

Année:

2013

Langue:

english

Fichier:

PDF, 455 KB

english, 2013

31

Predicting Pharmacokinetic Food Effects Using Biorelevant Solubility Media and Physiologically Based Modelling

Hannah M. Jones, Dr Neil Parrott, Gerd Ohlenbusch, Thierry Lavé

Journal:

Clinical Pharmacokinetics

Année:

2006

Langue:

english

Fichier:

PDF, 209 KB

english, 2006

32

Development of a Physiologically Based Model for Oseltamivir and Simulation of Pharmacokinetics in Neonates and Infants

Mr Neil Parrott, Brian Davies, Gerhard Hoffmann, Annette Koerner, Thierry Lave, Eric Prinssen, Elizabeth Theogaraj, Thomas Singer

Journal:

Clinical Pharmacokinetics

Année:

2011

Langue:

english

Fichier:

PDF, 218 KB

english, 2011

33

Physiologically Based Pharmacokinetic Modelling to Predict Single- and Multiple-Dose Human Pharmacokinetics of Bitopertin

Parrott, Neil, Hainzl, Dominik, Alberati, Daniela, Hofmann, Carsten, Robson, Richard, Boutouyrie, Bruno, Martin-Facklam, Meret

Journal:

Clinical Pharmacokinetics

Année:

2013

Langue:

english

Fichier:

PDF, 794 KB

english, 2013

34

In VitroandEx VivoInvestigation of the Impact of Luminal Lipid Phases on Passive Permeability of Lipophilic Small Molecules Using PAMPA

Markopoulos, Constantinos, Imanidis, Georgios, Vertzoni, Maria, Symillides, Mira, Parrott, Neil, Reppas, Christos

Journal:

Pharmaceutical Research

Année:

2013

Langue:

english

Fichier:

PDF, 272 KB

english, 2013

35

Dissolution media simulating the proximal canine gastrointestinal tract in the fasted state

Arndt, Marcel, Chokshi, Hitesh, Tang, Kin, Parrott, Neil J., Reppas, Christos, Dressman, Jennifer B.

Journal:

European Journal of Pharmaceutics and Biopharmaceutics

Année:

2013

Langue:

english

Fichier:

PDF, 525 KB

english, 2013

36

Use of physiologically based pharmacokinetic modeling for assessment of drug–drug interactions

Baneyx, Guillaume, Fukushima, Yumi, Parrott, Neil

Journal:

Future Medicinal Chemistry

Année:

2012

Langue:

english

Fichier:

PDF, 2.22 MB

english, 2012

37

Applications of a 7-day Caco-2 cell model in drug discovery and development

Peng, Ying, Yadava, Preeti, Heikkinen, Aki T., Parrott, Neil, Railkar, Aruna

Journal:

European Journal of Pharmaceutical Sciences

Année:

2014

Langue:

english

Fichier:

PDF, 1.18 MB

english, 2014

38

Physiologically based pharmacokinetic modeling of CYP3A4 induction by rifampicin in human: Influence of time between substrate and inducer administration

Baneyx, Guillaume, Parrott, Neil, Meille, Christophe, Iliadis, Athanassios, Lavé, Thierry

Journal:

European Journal of Pharmaceutical Sciences

Année:

2014

Langue:

english

Fichier:

PDF, 2.28 MB

english, 2014

39

Pharmacokinetics of Paracetamol in Göttingen Minipigs:In VivoStudies and Modeling to Elucidate Physiological Determinants of Absorption

Suenderhauf, Claudia, Tuffin, Gerald, Lorentsen, Helle, Grimm, Hans-Peter, Flament, Christophe, Parrott, Neil

Journal:

Pharmaceutical Research

Année:

2014

Langue:

english

Fichier:

PDF, 705 KB

english, 2014

40

Physiologically Based Absorption Modelling to Predict the Impact of Drug Properties on Pharmacokinetics of Bitopertin

Parrott, Neil, Hainzl, Dominik, Scheubel, Emmanuel, Krimmer, Siegfried, Boetsch, Christophe, Guerini, Elena, Martin-Facklam, Meret

Journal:

The AAPS Journal

Année:

2014

Langue:

english

Fichier:

PDF, 964 KB

english, 2014

41

The role of quantitative ADME proteomics to support construction of physiologically based pharmacokinetic models for use in small molecule drug development

Heikkinen, Aki T., Lignet, Floriane, Cutler, Paul, Parrott, Neil

Journal:

PROTEOMICS - Clinical Applications

Année:

2015

Langue:

english

Fichier:

PDF, 971 KB

english, 2015

42

Evaluating a physiologically based pharmacokinetic model for prediction of omeprazole clearance and assessing ethnic sensitivity in CYP2C19 metabolic pathway

Feng, Sheng, Cleary, Yumi, Parrott, Neil, Hu, Pei, Weber, Cornelia, Wang, Yongqing, Yin, Ophelia Q. P., Shi, Jun

Journal:

European Journal of Clinical Pharmacology

Année:

2015

Langue:

english

Fichier:

PDF, 447 KB

english, 2015

43

Blood Pressure Success Zone: You Auto Know A Worksite-Based Program to Improve Blood Pressure Control Among Auto Workers

Jackson, James, Kohn–Parrott, Kate A., Parker, Cyndy, Levins, Neil, Dyer, Susan, Hedalen, Erika J., Frank, Elaine, Bramer, Susan, Brandt, Debra, Doyle, Joseph J.

Journal:

Population Health Management

Année:

2011

Langue:

english

Fichier:

PDF, 408 KB

english, 2011

44

Impact of 100% Fruit Juice Consumption on Diet and Weight Status of Children: An Evidence-based Review

Crowe-White, Kristi, O'Neil, Carol E., Parrott, J. Scott, Benson-Davies, Sue, Droke, Elizabeth, Gutschall, Melissa, Stote, Kim S., Wolfram, Taylor, Ziegler, Paula

Journal:

Critical Reviews in Food Science and Nutrition

Année:

2015

Langue:

english

Fichier:

PDF, 403 KB

english, 2015

45

Investigating the effect of autoinduction in cynomolgus monkeys of a novel anticancer MDM2 antagonist, idasanutlin, and relevance to humans

Glenn, Kelli J., Yu, Li J., Reddy, Micaela B., Fretland, Adrian J., Parrott, Neil, Hussain, Sazzad, Palacios, Mary, Vazvaei, Faye, Zhi, Jianguo, Tuerck, Dietrich

Journal:

Année:

2015

Langue:

english

Fichier:

PDF, 558 KB

english, 2015

46

Metabolic Impact of 100% Fruit Juice Consumption on Antioxidant/oxidant Status and Lipid Profiles of Adults: An Evidence-based Review

Crowe-White, Kristi, Parrott, J. Scott, Stote, Kim S., Gutschall, Melissa, Benson-Davies, Sue, Droke, Elizabeth, O'Neil, Carol E., Wolfram, Taylor, Ziegler, Paula

Journal:

Critical Reviews in Food Science and Nutrition

Année:

2015

Langue:

english

Fichier:

PDF, 718 KB

english, 2015

47

Using Physiologically Based Pharmacokinetic (PBPK) Modelling to Gain Insights into the Effect of Physiological Factors on Oral Absorption in Paediatric Populations

Villiger, Angela, Stillhart, Cordula, Parrott, Neil, Kuentz, Martin

Journal:

The AAPS Journal

Année:

2016

Langue:

english

Fichier:

PDF, 828 KB

english, 2016

48

Combining ‘Bottom-Up’ and ‘Top-Down’ Methods to Assess Ethnic Difference in Clearance: Bitopertin as an Example

Feng, Sheng, Shi, Jun, Parrott, Neil, Hu, Pei, Weber, Cornelia, Martin-Facklam, Meret, Saito, Tomohisa, Peck, Richard

Journal:

Clinical Pharmacokinetics

Année:

2016

Langue:

english

Fichier:

PDF, 1.59 MB

english, 2016

49

Simulation-Based Evaluation of PK/PD Indices for Meropenem Across Patient Groups and Experimental Designs

Kristoffersson, Anders N., David-Pierson, Pascale, Parrott, Neil J., Kuhlmann, Olaf, Lave, Thierry, Friberg, Lena E., Nielsen, Elisabet I.

Journal:

Pharmaceutical Research

Année:

2016

Langue:

english

Fichier:

PDF, 1.36 MB

english, 2016

50

Outcome of Pancreas Transplantation in Recipients Older Than 50 Years: A Single-Centre Experience

Ablorsu, Elijah, Ghazanfar, Abbas, Mehra, Sanjay, Campbell, Babatunde, Riad, Hany, Pararajasingam, Ravi, Parrott, Neil, Picton, Michael, Augustine, Titus, Tavakoli, Afshin

Journal:

Transplantation Journal

Année:

2008

Langue:

english

Fichier:

PDF, 213 KB

english, 2008